This web page contains extensive information about alternative cancer treatment Paw Paw. It contains the details that support the Paw Paw ratings on the Comparison table*. Much of this information cannot be supplied by a Paw Paw distributor or manufacturer due to FDA regulations. All information is free and kept updated.

Thoughtful gifts for cancer patients: hypnosis CDs, and humor the best medicine.

Contact information of distributors is provided at the page botton in the How People Order section.

These Treatments are Different

You cannot pick an alternative cancer treatment the same way you pick your other medications. Despite the enthusiastic claims of well meaning people:

A person's unique body chemistry seems to be the most important consideration in selecting an alternative cancer treatment. Only energy medicine offers a selection method that takes body chemisrty into account.

What to Do

Consider the cocktail approach to preventing cancer cells from becoming drug resistant. Smart cancer patients are taking three or four treatments each of which were selected by different means such as:

After you have used a treatment for a while, drug resistance can prevent the treatment from continuing to be effective.  Successful cancer patients prevent drug restive cells from developing by using three or more alternative cancer treatments, the cocktail.


Paw Paw extract contains (among other active ingredients) acetogenins which modulate the production of ATP** (adenosine triphosphate) in mitochondria of cancer cells. This reduces the growth of blood vessels that nourish cancer cells. It also inhibits the growth of MDR (multiple drug resistance) cells. No other alternative or conventional cancer treatment (except treatments from trees similar to Paw Paw) has shown any effectiveness against MDR cells.

Paw Paw is a cousin of the graviola, guanabana, and soursop trees. However, the acetogenins extracted from Paw Paw are more active against cancer than those extracted from these other sources.

Fruit of the Paw Paw Tree

Multiple Drug Resistant Cells

Most tumors contain a small percentage, approximately 2%, of multiple drug-resistant cells (MDR cells). Chemo is not effective against these cells. After the first round of chemo, if the chemo is effective, all of the cells that are not MDR, do not show up in scans. Since this accounts for the vast majority of the tumor mass, the tumor will appear to be effectively gone (gone where is something to consider). However, the MDR cells remain and start to multiply. Eventually, a new tumor is formed that is entirely MDR. The next time chemo is used, none of the cells will disapear because they are all MDR. Paw Paw and Graviola are the only cancer treatments that have shown effectiveness against MDR cells.

Paul Winter now
offers phone consultations.


Paw Paw research was performed at Purdue College by Jerry McLaughlin. The majority of the funding (20 years and about 5 million dollars) for this research was provided by NCI. Jerry McLaughlin now works with Nature Sunshine who manufacture Paw Paw twig extract in capsule form.

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One of the effects of Paw Paw is to reduce the ATP energy in each cell of our body. Our cells have an electrical potential that effects how the cell processes energy producing substances mostly blood sugar and oxygen from our blood supply (the red area in the graphic below).

By reducing this voltage level from 70 to 110 mv to something in the 50 mv region, normal cells can still function. However, cancer and viral cells cannot process energy at this low voltage level and start to starve. The process of starving is a slower process than being poisoned which is why Paw Paw works slower than chemo. When Paw Paw does not work, it is usually because it is not absorbed sufficiently into the cells of the body to cause this voltage reduction. Both Cantron and Protocel are also designed to cause this voltage reduction. If Paw Paw does not work for a person, Cantron or Protocel may work. The pharmacology of Cantron and Protocel have an expanded explanation for the role ATP energy reduction in cancer treatment, for this text see the developer's explanation summarized by the webmaster Paul Winter .

Click this link for a 37 page, scientific paper (not for the laymen) on Paw Paw twig extract written in 1999 entitled "Annonaceous Acetogenins: Recent Progress."

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Blood Brain Barrier

Paw Paw is one of the few alternative cancer treatments that can pass the blood/brain barrier. The other alternative cancer treatments that can cross this barrier are Cantron and Protocel.


Paw Paw seems to work on all types of cancers. An informal study of 100 cancer patients showed that Paw Paw was effective in half the cases. This is most interesting since Paw Paw seems to work the same way that Cancell (Cantron and Protocel) works and Cancell also has a 50% effectiveness as demonstrated in another informal study. However, Paw Paw gets higher marks in the effectiveness because, in the laboratory, it inhibits the growth of MDR (multiple drug resistance) cells. No other cancer treatment including chemo has shown any effectiveness against MDR cells. Jerry McLaughlin is in the negotiation process for starting clinical trials in conjunction with Harvard University. However, no formal clinical trials have yet occurred. For more on MDR cells, see the "Multiple Drug Resistant Cells" section above.


Here are a few abstracts from studies conducted at Purdue University where most of the Paw Paw research for the past 30 years was conducted:

ABSTRACT: Cancer Letters 115 (1997) 73-79 The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells. Nicholas H. Oberlies, Vicki L. Croy, Marietta L. Harrison, Jerry L. McLaughlin Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University.

Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to the MCF-7/wt cells. ATP depletion is the mode of action of the Annonaceous acetogenins, and these agents offer a special advantage in the chemotherapeutic treatment of MDR tumors that have ATP-dependent mechanisms.

ABSTRACT: Journal of Medicinal Chemistry 1997, 40, 2102-2106 Structure-activity relationships of diverse Annonaceous acetogenins against multidrug-resistant human mammary adenocarcinoma (MCF-7/Adr) cells Nicholas H. Oberlies, Ching-jer Chang, Jerry L. McLaughlin Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University.

Fourteen structurally diverse Annonaceous acetogenins, representing the three main classes of bis-adjacent, bis-nonadjacent, and single-THF ring(s), were tested for their ability to inhibit the growth of adriamycin-resistant human mammary adenocarcinoma (MCF-7/Adr) cells. This cell line is resistant to treatment with adriamycin, vincristine, and vinblastine and is, thus, multidrug-resistant (MDR). Among a series of bis-adjacent THF ring acetogenins, those with the stereochemistry of threo-trans-threo-trans-erythro (from C-15 to C-24) were the most potent with as much as 250 times the potency of adriamycin. A spacing of 13 carbons between the flanking hydroxyl of the THF ring system and the gamma-unsaturated lactone seems to be optimum with a spacing of 11 and 9 carbons being significantly less active. Several single-THF ring compounds were also quite potent, with gigantetrocin A (11) being the most potent compound tested. The acetogenins may, thus, have chemotherapeutic potential, especially with regard to MDR tumors.

Copies of the journal articles mentioned in the story are available from the Purdue News Service, (765) 494-2081.

Additional Paw Paw research papers can be see at

Quantity of Papers

There have been over 100 scientific papers published on the chemistry and biology of the paw paw compounds.

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Paw Paw and Viruses

ATP is a direct and indirect precursor of DNA and RNA. This can slow or stop viral reproduction for viruses such as cold sores and shingles. Although the test results below show encouraging antiviral effect, it seems that Cancell (Cantron and Protocel) has a stronger antiviral effect. On the other hand Paw Paw has shown anecdotal evidence of being a strong anti-bacterial agent.

Conclusiveness of Papers

Almost all but research papers regarding Paw Paw demonstrate significant effectiveness in the laboratory against the usual form of cancer cells and MDR cells.

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Standalone Ability

Considering the performance of Paw Paw in a study of 94 terminal cancer patients and its performance against MDR cells, it seems that Paw Paw would stand alone as a cancer treatment very well. However, the manufacture and developer feel that the following supplements would aid Paw Paw:

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Dosage and Ease of Use

Paw Paw is easy to use. You only need two capsules, three times day, and taken with some food.

People who change their eating habits greatly increase the effectiveness of the supplements they take. Consider reading the Cancer Diets and pH* page.


In March 2009, the Paw Paw produced by Natures Sunshine had reduced concentration of active ingredients due to a low yield harvest. To compensate Natures Sunshine increased the number of capsules in the bottle. Now the recommended dose for the new 8 mg of Asimina triloba per Paw Paw capsules is 2 capsules three times a day with food to avoid nausea.

Increased Dosage

Some people have had success gradually increasing the Paw Paw dosage up to 16 capsules a day. They have done this very gradually in order to avoid nausea.

Paw Paw and Cantron or Protocel

It is suggested to avoid food for 15 minutes before and after taking Cantron or Protocel, but to take Paw Paw with food. Taking Cantron or Protocel fifteen minutes before or after taking Paw Paw with some food does not seem to have a significant effect on the the performance of either treatment. See Cantron or Protocel and Paw Paw just below.

Regardless of treatment, recovery is much more likely if the emotional component
is addressed. Visit the Tapping DVD page to learn about the simplest and
most effective method to remove emotional bocks to your healing.

Side Effects

Paw Paw gravitates toward cells that use a lot of energy and cut off their energy supply. Since cancer cells use 10-17 times as much energy as a normal cell, Paw Paw acts on cancer cells. It is the same mechanism that made it so useful as a parasite cleanse and to kill hair lice. It is also the reason that a pregnant woman should not take it. Paw Paw could see the baby as a high energy user.

If no cancer, parasite, or other high energy consumer cells reside in the body, Paw Paw may gravitate towards fast growing cells lining the digestive and intestinal system walls. This is why the manufacturer, Nature's Sunshine, strongly cautions against long term use for non-cancer patients.

Some people with cancer have reported digestion distress such as nausea. For this reason it is recommended to take Paw Paw with food.

Cantron or Protocel and Paw Paw

You can take Protocel with Paw Paw, but don't forget to read all the Paw Paw protocols under the Dosage and Ease of Use (above) and Compatability (just below) sections. Some people respond very quickly to Cantron or Protocel. In this case the body may have excessive waste material to remove. Paw Paw can increase the response of your body and overload the waste removal system. To present this overload, some people start Paw Paw 3 to 5 weeks after starting Cantron or Protocel or starting Paw Paw before Cantron or Protocel.

You should avoid food for 15 minutes before and after taking Cantron or Protocel, but you should have some food with Paw Paw.  therefore, people take the Cantron or Protocel first, wait 15 minutes, eat a little and take the PawPaw. New recommended doseage for Paw Paw is 2 capsule three times a day. Since the recommended dose for Cantron or Protocel is six times a day, you alternate taking Paw Paw with Cantron or Protocel with just taking Cantron or Protocel. For example:

6 AM Cantron or Protocel, 6:15 AM Paw Paw

10 AM Cantron or Protocel

2 PM Cantron or Protocel, 2:15 PM Paw Paw

6 PM Cantron or Protocel

10 PM Cantron or Protocel, 10:15 PM Paw Paw

2 AM Cantron or Protocel

Since Paw Paw is fat soluble it will work better after a person has started eating for the day. Therefore, some users start taking Paw Paw with the second dose of Cantron or Protocel. See the Dosage section just above.

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Paw Paw seems to work in a similar manner to Cancell and may reduce the side effects of chemo, but does not interfere with chemo.

Warning: If a cancer patient uses Paw Paw during a course of chemo, the reduced side effects caused by Paw Paw may encourage the oncologist to increase the dose of chemo. If the patient then decides to stop the Paw Paw, for whatever reason, the side effects of chemo can increase and greatly threaten the patients life.

One of the ways that Paw Paw works is to prevent cancer cells from feeding on glucose by reducing the ATP energy of the cells in our body. The substances in the following list increase ATP energy and should therefore be avoided when taking Paw Paw. Some people believe that you can take some of these things with Paw Paw because they were tested with Paw Paw and Paw Paw was still able to kill cancer cells in test tubes. However, Paw Paw works in a number of ways and those other ways may have been responsible for how Paw Paw worked with some of the things on this list.

Vitamins to Avoid

High concentrations of the following substances have been known to interfere with Cantron (naturally occurring quantities in food has not caused any problems):
Vitamin C (taking vitamin C is the number one reason that Paw Paw fails to work)
Vitamin E
Thyroid support products
CoEnzyme Q10
"sea greens" such as spirulina, algae, chlorella, kelp may have a problem
The amount of vitamins found in fruits and vegetables will not have a serious effect on the performance of Paw Paw.

The following counter the effects of Paw Paw:

Burdock Root
Essiac tea and Flor-Essence (which is similar to Essiac with a couple of extra ingredients)
Ozone treatments ( oxygen treatments such as hyperbaric oxygen are beneficial to the functioning of Protocel)
Flax seed oil as used in the Budwig diet (also spelled flaxseed oil). It is starting to appear that flax seed oil may be compatible, but it remains on this list as a precaution
IP6 (in theory there may be a problem, but case histories are needed)
Hydrogen peroxide
PMB Techno
Rhodiola Rhosea
Magnesium In higher doses, magnesium is credited with increasing ATP production.
Colloidal silver
- the heavy metal quality of silver could cause a reaction with Protocel.
Pau d'arco with Germanium-132 (taking either separately with Protocel is OK)
Grapefruit seed extract (due to its high vitamin C content)
Whey protein should also be avoided because of the L-cysteine
Cesium Chloride
because of the alpha-lipoic acid
Hormone-Blocking Drugs

MMS (Miracle Mineral Supplement) chlorine dioxide
Sulfhydrazly antioxidants which includes:

Alpha-lipoic acid

For a list of treatments that are believed to be compatible with Paw Paw see the "Treatments that Can Be Taken with Cantron" list in the Compatibility section of the Cantron page.

Year Available

Paw Paw was made available for purchase by Nature's Sunshine in 2003. Since Paw Paw and graviola are so closely related it should be noted that graviola has been under study and available to a limited extent since the 1940's.

Relative Cost per Month

A one-month supply of Paw Paw costs $40 for 180 capsules. The standard dose is six capsules a day so one bottle is a one month supply. This makes Paw Paw one of the least expensive alternative cancer treatment available. Each capsule contains 8 mg of standardized paw paw extract Asimina triloba.

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Insure Success After Ordering Paw Paw
Almost every cancer survivor who used alternatives used two or more treatments. After you order Paw Paw, ask your body to select a cancer treatment to add to your protocol using the Alternative Cancer Test Kit*.

Avoid Critical Gaps in Your Protocol

There are many therapies described on this web site some of which will perfectly match your needs. However, this web site is huge, if you do not already know what to look for, you may not find what you need. For example, JR who had the two week remission (see the top of the Test Kit page) chose to follow all the therapies we developed during our phone consultation, but half of them he had not come across on my web site.

When you purchase a phone consultation all the therapies that we decide are right for you will be explored during the consultation and included in a meticulously prepared summary of about 20 pages containing all the details of the consultation. The two hours consultation and summary is only $150 and comes with an unconditional guarantee:

After the consultation, you will have priority status for email replies. We will respond to your emails quickly, night and day, and on weekends. Don't go it alone.

Paul Winter


Paw Paw is not sold by this web site (ordering links are below the pictures). This web site offers the following tools for cancer patients. The CD and DVD combo* is the best value. The phone consultation* is the most valuable.

Use the Test Kit* to allow your body to select the best treatment. EMF Protection* can protect you from cell phones, wi-fy and a plethora of electromagnetic pollution.
Our bodies are often not aware that tumors are a threat until it is too late. Hypnosis CDs* can send a clear message that the body needs to start to take care of this threat. Recovery from cancer is more likely if the emotional component is addressed. This tool is the simplest and most effective method to remove emotional bocks to your healing. Tapping DVD*.
Laughter instantly reduces symptoms of a wide range of disorders. Order the joke book* and laugh your way to a recovery. Energy medicine* is the medicine of the future. Wearing a pendant or a bracelet allows you to have the benefit of this technology every minute of every day.
Nothing on this web site is as helpful as a phone consultation*. It is the fastest way to assure the best comprehensive approach* for you. When your cancer treatment starts working, your lymph system will need all the help it can get. This double roller massager* gets the lymph moving.

Paw Paw Ordering

Before you leave this web site to order Paw Paw, please go to our Shopping cart and complete your order of any of the above tools. To return here, just use your Back button repeatedly.

The best brand of Paw Paw is Nature's Sunshine. Here are two US distributors:

John Howlett Nature's Sunshine Regional Manager For ordering online in the US** or for ordering overseas**. Although John is  prevented, by FDA regulations, from making medical claims, he makes himself available to discuss protocols through this email form or at his toll free ordering number: 888 523-1727.

New Beginnings in Health- For ordering worldwide**. You can call Richard on his toll free line from the US 1 877 871-6262 from outside the US 818-994-6693. Richard is not medically trained, nor can guarantee effectiveness. There is a video in nine parts of Dr. McLaughlin's lecture starting here. Email Richard.

Any Nature's Sunshine distributor can obtain Paw Paw for you.

International Distributors

Go to the Nature's Sunshine Products** page and click on Select a Region in the upper right corner. If your country isn't listed, go to John & Roxanne Howlett's international ordering page** (see their other contact information just below).


Tracy Arnholtz can be reached toll free phone from Canada and the United States  866-350-0073.

The Best Present

Without a doubt the best present you can give a cancer patient is a spontaneous remission, consider learning more about hypnosis CDs and spontaneous remissions, click the CD.

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